Pik3r1^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pik3r1^m3Btlr
• Name: phosphoinositide-3-kinase regulatory subunit 1; mutation 3, Bruce Beutler
• MGI ID: MGI:6286124
• Synonyms: astro_boy
• Gene: Pik3r1 Location: Chr13:101817269-101904725 bp, - strand Genetic Position: Chr13, 53.92 cM
• Alliance: Pik3r1^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 101,701,732 (v38) on chromosome 13, or base pair 66,486 in the GenBank genomic region NC_000079 encoding Pik3r1. The mutation corresponds to residue 1,436 in the mRNA sequence NM_001077495 within exon 6 of 16 total exons. The mutation results in a leucine to histidine substitution at residue 272 (L272H) in the p85 protein. (J:272853)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3r1 Mutation: 56 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3807

References

• Original: J:272853 Zhong X, et al., Mutagenetix entry for astro_boy. MGI Direct Data Submission. 2019
• All: 1 reference(s)