Plcg2^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Plcg2^m4Btlr
• Name: phospholipase C, gamma 2; mutation 4, Bruce Beutler
• MGI ID: MGI:6286285
• Synonyms: trident
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 117,612,978 (v38) on chromosome 8, or base pair 114,704 in the GenBank genomic region NC_000074 encoding Plcg2. The mutation corresponds to residue 3,328 in the mRNA sequence NM_172285 within exon 28 of 33 total exons. The mutation results in a methionine to valine substitution at position 1,043 (M1043V) in the phospholipase C gamma 2 (PLC-2) protein. (J:272862)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3949

References

• Original: J:272862 Zhong X, et al., Mutagenetix entry for trident. MGI Direct Data Submission. 2019
• All: 1 reference(s)