Zap70^m8Btlr
Chemically induced Allele Detail

Summary

• Symbol: Zap70^m8Btlr
• Name: zeta-chain (TCR) associated protein kinase; mutation 8, Bruce Beutler
• MGI ID: MGI:6286299
• Synonyms: want_to
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^m8Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 36,782,517 (v38) on chromosome 1, or base pair 20,720 in the GenBank genomic region NC_000067 encoding Zap70. The mutation corresponds to residue 1,952 in the mRNA sequence NM_001289766 within exon 13 of 13 total exons. The mutation results in a tyrosine to cysteine substitution at position 597 (Y597C) in the ZAP70 protein. (J:272864)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4037

References

• Original: J:272864 Zhong X, et al., Mutagenetix entry for want_to. MGI Direct Data Submission. 2019
• All: 1 reference(s)