Tg(Myoc*Y423H)#Sit
Transgene Detail

Summary

• Symbol: Tg(Myoc*Y423H)#Sit
• Name: transgene insertion, Stanislav I Tomarev
• MGI ID: MGI:6286495
• Transgene: Tg(Myoc*Y423H)#Sit Location: unknown
• Alliance: Tg(Myoc*Y423H)#Sit page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myoc*Y423H)#Sit expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myoc (MGI:1202864)	mutation corresponds to the severe glaucoma-causing Tyr437His mutation in human

• Mutation details: This transgene consists of BAC DNA 16652 containing the full-length mouse myocilin with a Tyr423His point mutation (T to C in codon 423) as well as 20 and 85.5 kb of the 5'-flanking and 3'-flanking sequences. This mutation corresponds to the severe glaucoma-causing Tyr437His mutation in human. Several lines were generated, however one line containing 2-3 copies of the mutated gene was used for analysis. The pound symbol (#) is used when line is not specified. (J:116124)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:116124 Senatorov V, et al., Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice. J Neurosci. 2006 Nov 15;26(46):11903-14
• All: 2 reference(s)