Trim59^tm1Ryag
Targeted Allele Detail

Summary

• Symbol: Trim59^tm1Ryag
• Name: tripartite motif-containing 59; targeted mutation 1, Rongcun Yang
• MGI ID: MGI:6287110
• Synonyms: Trim59-
• Gene: Trim59 Location: Chr3:68942625-68952075 bp, - strand Genetic Position: Chr3, 32.16 cM, cytoband E2
• Alliance: Trim59^tm1Ryag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272362
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 147 bp of intron 2 and the entire coding region of Trim59 were deleted and replaced with a floxed neomycin resistance cassette. (J:272362)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim59 Mutation: 55 strains or lines available

References

• Original: J:272362 Su X, et al., Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death Dis. 2018 Feb 21;9(3):302
• All: 1 reference(s)