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Tg(tetO-DISC1*)1302BPlet
Transgene Detail
Summary
Symbol: Tg(tetO-DISC1*)1302BPlet
Name: transgene insertion 1302B, Mikhail Pletnikov
MGI ID: MGI:6287123
Transgene: Tg(tetO-DISC1*)1302BPlet  Location: unknown  
Alliance: Tg(tetO-DISC1*)1302BPlet page
Transgene
origin
Strain of Origin:  C57BL/6 and SJL
Transgene
description
Transgene Type:    Transgenic (Epitope tag, Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO-DISC1*)1302BPlet expresses 1 gene
 
Mutation detailsThe transgene construct was designed with the myc peptide tagged mutant (truncated) human DISC1 (disrupted in schizophrenia 1) gene, under the control of tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequence and a cytomegalovirus minimal promoter. Line 1302B shows a relatively weak expression of human DISC1. (J:146881)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
behavior/neurological
behavior/neurological phenotype
N
enhanced behavioral response to xenobiotic
increased locomotor activity
homeostasis/metabolism
abnormal serine level
decreased serine level
nervous system
nervous system phenotype
N
decreased prepulse inhibition
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:146881 Pletnikov MV, et al., Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry. 2008 Feb;13(2):173-86, 115
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory