Tg(tetO-DISC1*)1302BPlet
Transgene Detail
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Symbol: |
Tg(tetO-DISC1*)1302BPlet |
Name: |
transgene insertion 1302B, Mikhail Pletnikov |
MGI ID: |
MGI:6287123 |
Transgene: |
Tg(tetO-DISC1*)1302BPlet Location: unknown
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Alliance: |
Tg(tetO-DISC1*)1302BPlet page
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Strain of Origin: |
C57BL/6 and SJL
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Transgene Type: |
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Transgenic (Epitope tag, Humanized sequence, Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(tetO-DISC1*)1302BPlet expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
DISC1 (27185) |
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Mutation details: The transgene construct was designed with the myc peptide tagged mutant (truncated) human DISC1 (disrupted in schizophrenia 1) gene, under the control of tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequence and a cytomegalovirus minimal promoter. Line 1302B shows a relatively weak expression of human DISC1.
(J:146881)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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√
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behavior/neurological phenotype
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N
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enhanced behavioral response to xenobiotic
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√
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increased locomotor activity
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√
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homeostasis/metabolism
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√
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abnormal serine level
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√
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decreased serine level
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√
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nervous system
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√
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nervous system phenotype
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N
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decreased prepulse inhibition
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:146881 Pletnikov MV, et al., Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry. 2008 Feb;13(2):173-86, 115 |
All: |
6 reference(s) |
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