Arhgef10^tm1.1Ssfg
Targeted Allele Detail

Summary

• Symbol: Arhgef10^tm1.1Ssfg
• Name: Rho guanine nucleotide exchange factor 10; targeted mutation 1.1, Susan Shur-Fen Gau
• MGI ID: MGI:6287205
• Synonyms: Arhgef10^-
• Gene: Arhgef10 Location: Chr8:14961663-15051085 bp, + strand Genetic Position: Chr8, 7.59 cM
• Alliance: Arhgef10^tm1.1Ssfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271943
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exons 4 and 5. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 4 and 5 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the brain of adult homozygous mutant mice. (J:271943)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef10 Mutation: 69 strains or lines available

References

• Original: J:271943 Lu DH, et al., Impairment of social behaviors in Arhgef10 knockout mice. Mol Autism. 2018;9:11
• All: 2 reference(s)