Cenpf^em1Bko
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cenpf^em1Bko
• Name: centromere protein F; endonuclease-mediated mutation 1, Benoit Kornmann
• MGI ID: MGI:6287437
• Synonyms: CENP-F^F2872A, cenpf^[p.F872A]BKL
• Gene: Cenpf Location: Chr1:189372803-189420283 bp, - strand Genetic Position: Chr1, 95.03 cM
• Alliance: Cenpf^em1Bko page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced a TT to GC mutation in exon 17 resulting in a phenylalanine to alanine substitution at amino acid 2872 (F2872A). This mutation is within the Rhot (Miro)-binding region and is predicted to abolish Rhot-binding. (J:273098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cenpf Mutation: 109 strains or lines available

References

• Original: J:273098 Peterka M, et al., Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice. PLoS Genet. 2019 Mar;15(3):e1008050
• All: 1 reference(s)