Gprasp2^tm1.1Jpe
Targeted Allele Detail

Summary

• Symbol: Gprasp2^tm1.1Jpe
• Name: G protein-coupled receptor associated sorting protein 2; targeted mutation 1.1, Joao Peca
• MGI ID: MGI:6287842
• Gene: Gprasp2 Location: ChrX:134739786-134745480 bp, + strand Genetic Position: ChrX, 57.3 cM
• Alliance: Gprasp2^tm1.1Jpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273373
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 was flanked by loxP sites and an frt-flanked neomycin cassette was inserted downstream of the floxed exon. Germline cre-mediated recombination deleted exon 7. (J:273373)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprasp2 Mutation: 8 strains or lines available

References

• Original: J:273373 Edfawy M, et al., Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice. Nat Commun. 2019 Mar 29;10(1):1431
• All: 1 reference(s)