Arhgef10l^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgef10l^em1(IMPC)J
• Name: Rho guanine nucleotide exchange factor 10-like; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6293909
• Gene: Arhgef10l Location: Chr4:140241796-140393318 bp, - strand Genetic Position: Chr4, 71.58 cM
• Alliance: Arhgef10l^em1(IMPC)J page
• IMPC: Arhgef10l gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TGTTCTGACTTGAAACGGAA and CCCGCCCCTCGAAGGAACCA, which resulted in a 413 bp deletion beginning at Chromosome 4 position 140,610,248 bp and ending after 140,610,660 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000335941 (exon 4) and 379 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 74 and early truncation 43 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Arhgef10l Mutation: 60 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)