Hgf^tm1.1Tbf
Targeted Allele Detail

Summary

• Symbol: Hgf^tm1.1Tbf
• Name: hepatocyte growth factor; targeted mutation 1.1, Thomas B Friedman
• MGI ID: MGI:6294039
• Synonyms: Hgf^del10
• Gene: Hgf Location: Chr5:16758493-16825150 bp, + strand Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
• Alliance: Hgf^tm1.1Tbf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289982
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The allele contains a 10 bp deletion (AAGATGATGA) in intron 5 (NM_001289458), and occurs beginning +1990 from end of exon 5 and -3632 from the beginning of exon 6 (NM_001289458). A 1.863 kb floxed Neo selection casette was introduced in intron 5 at chr5:16,569,650 (GRCm38/mm10) in the original line. Cre-mediated recombination removed the selection cassette. (J:289982)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgf Mutation: 55 strains or lines available

References

• Original: J:289982 Morell RJ, et al., Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39. J Neurosci. 2020 Apr 8;40(15):2976-2992
• All: 1 reference(s)