Sptan1^tm1.1Mnr
Targeted Allele Detail

Summary

• Symbol: Sptan1^tm1.1Mnr
• Name: spectrin alpha, non-erythrocytic 1; targeted mutation 1.1, Matthew N Rasband
• MGI ID: MGI:6294093
• Synonyms: Sptan1^f
• Gene: Sptan1 Location: Chr2:29855572-29921463 bp, + strand Genetic Position: Chr2, 20.93 cM, cytoband B
• Alliance: Sptan1^tm1.1Mnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254073
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-flanked neomycin selection cassette and loxP sites flanking exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette (J:254073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sptan1 Mutation: 130 strains or lines available

References

• Original: J:254073 Huang CY, et al., alphaII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci. 2017 Nov 22;37(47):11311-11322
• All: 3 reference(s)