Ergic1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ergic1^em1(IMPC)J
• Name: endoplasmic reticulum-golgi intermediate compartment 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6294102
• Gene: Ergic1 Location: Chr17:26780463-26875908 bp, + strand Genetic Position: Chr17, 13.34 cM, cytoband B1
• Alliance: Ergic1^em1(IMPC)J page
• IMPC: Ergic1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GGAGCAGCCCGCTTCTACAG and GCTGGAGTGGAAATTACCAA, which resulted in a 365 bp deletion beginning at Chromosome 17 position 26,629,494 bp and ending after 26,629,858 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001241041 (exon 5) and 240 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 83 and early truncation 26 amino acids later.
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ergic1 Mutation: 130 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)