H2^nc
Spontaneous Allele Detail

Summary

• Symbol: H2^nc
• Name: histocompatibility-2, MHC; nc variant
• MGI ID: MGI:6294255
• Synonyms: H2^dm7
• Gene: H2 Location: unknown Genetic Position: Chr17, cytoband B-C

Mutation origin

• Strain of Origin: NC/Nga

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Not Applicable
• Mutation details: A H2-D^d/H2-L^d hybrid mutant transcript consisting of sequences encoding a fusion protein containing 1/4 of the N terminal of H2-D^d and 3/4 of the C terminus of L^d is formed in NC/Nga mice. This transcript differs from the similar H2^d transcripts in that there are 22 novel mutations at the amino-acid (aa) level in the fusion H2 protein in NC/Nga mice compared to mice carrying H2^d. (J:273488)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2 Mutation: 281 strains or lines available

References

• Original: J:273488 Ohkusu-Tsukada K, et al., Low expression of a D(dm7)/L(dm7)-hybrid mutant (D/L(dm7)) in the novel haplotype H-2(nc) identified in atopic dermatitis model NC/Nga mice. Genes Immun. 2019 Jan;20(1):74-81
• All: 2 reference(s)