Nsun5^em1Lgch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nsun5^em1Lgch
• Name: NOL1/NOP2/Sun domain family, member 5; endonuclease-mediated mutation 1, Ling Chen
• MGI ID: MGI:6294475
• Gene: Nsun5 Location: Chr5:135398807-135405659 bp, + strand Genetic Position: Chr5, 75.16 cM
• Alliance: Nsun5^em1Lgch page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 3 deleted 1 bp in addition to a further 21 bp deletion. (J:271670)

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsun5 Mutation: 30 strains or lines available

References

• Original: J:271670 Zhang T, et al., Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells. Glia. 2019 Apr;67(4):688-702
• All: 4 reference(s)