Tg(Myh6*/tetO-BAG3)69Atsa
Transgene Detail

Summary

• Symbol: Tg(Myh6*/tetO-BAG3)69Atsa
• Name: transgene insertion 69, Atsushi Sanbe
• MGI ID: MGI:6294697
• Synonyms: BAG3 TG
• Transgene: Tg(Myh6*/tetO-BAG3)69Atsa Location: unknown
• Alliance: Tg(Myh6*/tetO-BAG3)69Atsa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6*/tetO-BAG3)69Atsa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BAG3 (9531)

  Bag3	(MGI:1352493)

• Mutation details: The human Bcl-2 associated athanogene cDNA was inserted into an MHCminTetO-promoter construct. The expression of the construct was driven by the mouse alpha-myosin heavy chain promoter with 3 altered GATA sites and 2 altered thyroid-like response elements for maintaining low levels of cardiac-specific expression, under the control of a tetracycline operator. (J:273465)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:273465 Inomata Y, et al., Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart. Biochem Biophys Res Commun. 2018 Feb 19;496(4):1141-1147
• All: 1 reference(s)