Nek1^em13Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nek1^em13Lutzy
• Name: NIMA (never in mitosis gene a)-related expressed kinase 1; endonuclease-mediated mutation 13, Cathy Lutz
• MGI ID: MGI:6295435
• Synonyms: Nek1^R549X
• Gene: Nek1 Location: Chr8:61446229-61584380 bp, + strand Genetic Position: Chr8, 30.91 cM
• Alliance: Nek1^em13Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing is used to introduce the R549X mutation, and the silent A548A mutation. The mouse Nek1 R549X mutation is equivalent to the human R550X NEK1 mutation and is associated with amyotrophic lateral sclerosis. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nek1 Mutation: 83 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)