Vldlr^rnv4
Spontaneous Allele Detail

Summary

• Symbol: Vldlr^rnv4
• Name: very low density lipoprotein receptor; retinal neovascularization 4
• MGI ID: MGI:6295987
• Gene: Vldlr Location: Chr19:27193884-27231631 bp, + strand Genetic Position: Chr19, 21.77 cM
• Alliance: Vldlr^rnv4 page

Mutation origin

• Strain of Origin: C57BLKS/J-Npc1^spm/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: This spontaneous A to G transition next to a single base pair (A) deletion in exon 12 results in a frameshift and premature stop codon at amino acid 540. (J:274099)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vldlr Mutation: 69 strains or lines available

References

• Original: J:274099 Chang B, et al., A new mouse model of early-onset neovascularization 4 (rnv4). Journal Invest Ophthalmol Vis Sci. 2019-07;60(9):1641 (Abstr.)
• All: 1 reference(s)