Abraxas1^tm1.1Bwng
Targeted Allele Detail

Summary

• Symbol: Abraxas1^tm1.1Bwng
• Name: BRCA1 A complex subunit; targeted mutation 1.1, Bin Wang
• MGI ID: MGI:6296766
• Synonyms: Abraxas^delta
• Gene: Abraxas1 Location: Chr5:100953058-100968831 bp, - strand Genetic Position: Chr5, 48.52 cM
• Alliance: Abraxas1^tm1.1Bwng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269823
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Cre-mediated recombination removed the selection cassette and exon 5. Immunoblotting confirmed the absence of protein in mouse embryonic fibroblast. (J:269823)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abraxas1 Mutation: 20 strains or lines available

References

• Original: J:269823 Castillo A, et al., The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell Rep. 2014 Aug 7;8(3):807-17
• All: 1 reference(s)