Syne2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Syne2^em1(IMPC)J
• Name: spectrin repeat containing, nuclear envelope 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6302762
• Gene: Syne2 Location: Chr12:75865092-76157702 bp, + strand Genetic Position: Chr12, 33.11 cM
• Alliance: Syne2^em1(IMPC)J page
• IMPC: Syne2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CATTCCCTAAAGATCCCACT and CTGCTCACAGCAATAAACAA, which resulted in a 640 bp deletion beginning at Chromosome 12 position 75,887,919 bp and ending after 75,888,558 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001247793 (exon 7) and 452 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 136 and early truncation 1 amino acid later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Syne2 Mutation: 297 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)