Gen1^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Name: GEN1, Holliday junction 5' flap endonuclease; transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:6303587
• Synonyms: Gen1^PB
• Gene: Gen1 Location: Chr12:11288921-11315802 bp, - strand Genetic Position: Chr12, 5.58 cM
• Alliance: Gen1^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Hypomorph)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. Line 1 inserted into the second intron (Chr:12.11268138, Ensembl release 54). (J:123680, J:272082)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gen1 Mutation: 58 strains or lines available

References

• Original: J:272082 Wang H, et al., Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice. Int J Biol Sci. 2018;14(1):10-20
• All: 6 reference(s)