Atp6v0a2^tm1Kdb
Targeted Allele Detail

Summary

• Symbol: Atp6v0a2^tm1Kdb
• Name: ATPase, H+ transporting, lysosomal V0 subunit A2; targeted mutation 1, Kenneth D Beaman
• MGI ID: MGI:6303630
• Synonyms: a2V^f, a2V^fl
• Gene: Atp6v0a2 Location: Chr5:124767117-124801519 bp, + strand Genetic Position: Chr5, 63.7 cM
• Alliance: Atp6v0a2^tm1Kdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-FRT flanked neo cassette was introduced upstream of exon 12 and a third loxP was inserted downstream of exon 14. (J:274047)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb Tg(MMTV-cre)4Mam/0	involves: 129 * C57BL/6 * FVB
cn2	Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca

Phenotypes:

Affected Systems	cn1	cn2
show or hide all annotated terms Sex:
endocrine/exocrine glands	√
abnormal mammary gland development	√
impaired mammary gland growth during pregnancy	√
abnormal mammary gland epithelium morphology	√
abnormal mammary gland duct morphology	√
abnormal branching of the mammary ductal tree	√
abnormal mammary duct terminal end bud morphology	√
abnormal lactation	√
hematopoietic system		√
decreased T cell number		√
decreased alpha-beta T cell number		√
decreased CD4-positive, alpha-beta T cell number		√
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology		√
immune system		√
decreased T cell number		√
decreased alpha-beta T cell number		√
decreased CD4-positive, alpha-beta T cell number		√
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology		√
integument	√
abnormal mammary gland development	√
impaired mammary gland growth during pregnancy	√
abnormal mammary gland epithelium morphology	√
abnormal mammary gland duct morphology	√
abnormal branching of the mammary ductal tree	√
abnormal mammary duct terminal end bud morphology	√
abnormal lactation	√
neoplasm		√
increased metastatic potential		√
increased incidence of induced tumors		√
decreased tumor latency		√
reproductive system	√
impaired mammary gland growth during pregnancy	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp6v0a2 Mutation: 52 strains or lines available

References

• Original: J:274047 Pamarthy S, et al., The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-beta signaling. Cell Death Dis. 2016 Nov 3;7(11):e2443
• All: 4 reference(s)