Lmbr1l^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lmbr1l^m1Btlr
• Name: limb region 1 like; mutation 1, Bruce Beutler
• MGI ID: MGI:6303733
• Synonyms: Lmbr1l^st, strawberry
• Gene: Lmbr1l Location: Chr15:98801798-98815944 bp, - strand Genetic Position: Chr15, 55.1 cM
• Alliance: Lmbr1l^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: C to A transversion at base pair 98,909,263 (v38) on chromosome 15, or base pair 8,986 in the GenBank genomic region NC_000081 encoding Lmbr1l. The mutation corresponds to residue 813 (c.813C>A) in the mRNA sequence NM_029098.3 within exon 8 of 17 total exons. The mutation results in substitution of cysteine 212 to a premature stop codon (p.C212*) in the LMBR1L protein. (J:274568)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmbr1l Mutation: 34 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=2444

References

• Original: J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
• All: 1 reference(s)