Lmbr1l^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lmbr1l^em1Btlr
• Name: limb region 1 like; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6303829
• Gene: Lmbr1l Location: Chr15:98801798-98815944 bp, - strand Genetic Position: Chr15, 55.1 cM
• Alliance: Lmbr1l^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The CRISPR/Cas9 system and sgRNA 5'-TGCACTCGCGGACCCTGTCG-3' was used to generate the mice. The CRISPR/Cas9 system generated a 2-base pair deletion at c.231_232del (NM_029098.3). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 17 of the protein and premature termination after the inclusion of 30 aberrant amino acids. (J:274568)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmbr1l Mutation: 34 strains or lines available

References

• Original: J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
• All: 1 reference(s)