Gh^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Gh^m1Btlr
• Name: growth hormone; mutation 1, Bruce Beutler
• MGI ID: MGI:6303931
• Synonyms: atto
• Gene: Gh Location: Chr11:106191097-106192691 bp, - strand Genetic Position: Chr11, 68.89 cM, cytoband D
• Alliance: Gh^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 106,301,404 (v38) on chromosome 11, or base pair 2,300 in the GenBank genomic region NC_000077.6. The mutation corresponds to residue 310 (c.310A>T) in the mRNA sequence NM_008117.3 within exon 2 of 5 total exons. The mutation results in substitution of lysine 55 for a premature stop codon (p.K55*) in the GH protein. (J:274650)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gh Mutation: 16 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4178

References

• Original: J:274650 Zhang Z, et al., Mutagenetix entry for atto. MGI Direct Data Submission. 2019
• All: 1 reference(s)