Il1r2^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il1r2^tm1Yiw
• Name: interleukin 1 receptor, type II; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:6303948
• Gene: Il1r2 Location: Chr1:40123872-40164390 bp, + strand Genetic Position: Chr1, 18.65 cM
• Alliance: Il1r2^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274653
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The chromosome region containing the second, third, and fourth exons of the gene, which ranged from the initiation codon ATG to an EcoRV site just after the fourth exon, was replaced by a 2.5-kb DNA fragment containing the EGFP gene and a loxP-flanked neomycin resistance cassette. No detectable wild type transcript is expressed from this allele. EGFP is expressed under the control of the endogenous gene promoter. (J:274653)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1r2 Mutation: 32 strains or lines available

References

• Original: J:274653 Shimizu K, et al., IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages. J Immunol. 2015 Apr 1;194(7):3156-68
• All: 2 reference(s)