Fam168a^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fam168a^em1(IMPC)J
• Name: family with sequence similarity 168, member A; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6304254
• Gene: Fam168a Location: Chr7:100355842-100490863 bp, + strand Genetic Position: Chr7, 54.39 cM
• Alliance: Fam168a^em1(IMPC)J page
• IMPC: Fam168a gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CCCTCAGTCCTGGTGCCCAT and GCTGGAGGCTCCCGGAGAAG, which resulted in a 432 bp deletion beginning at Chromosome 7 position 100,831,131 bp and ending after 100,831,562 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000335948 (exon 6) and 289 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 93 and truncation 116 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fam168a Mutation: 101 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)