Themis^m5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Themis^m5Btlr
• Name: thymocyte selection associated; mutation 5, Bruce Beutler
• MGI ID: MGI:6304287
• Synonyms: six_flags
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^m5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 28,781,907 (v38) on chromosome 10, or base pair 113,581 in the GenBank genomic region NC_000076 encoding Themis. The mutation corresponds to residue 1,229 in the mRNA sequence NM_178666 within exon 4 of 6 total exons. The mutation results in an isoleucine to threonine substitution at position 310 (I310T) in the Themis protein. (J:274716)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 57 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4154

References

• Original: J:274716 Zhong X, et al., Mutagenetix entry for six_flags. MGI Direct Data Submission. 2019
• All: 1 reference(s)