Lepr^m10Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lepr^m10Btlr
• Name: leptin receptor; mutation 10, Bruce Beutler
• MGI ID: MGI:6304291
• Synonyms: donner
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^m10Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to A transversion at base pair 101,815,201 (v38) on chromosome 4, or base pair 98,068 in the GenBank genomic region NC_000070. The mutation corresponds to residue 3,973 in the mRNA sequence NM_146146 within exon 19 of 19 total exons. The mutation results in a glutamine to lysine substitution at position 1,141 (Q1141K) in the LEPR protein. (J:274729)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:274729 Zhang Z, et al., Mutagenetix entry for donner. MGI Direct Data Submission. 2019
• All: 1 reference(s)