Kcna2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Kcna2^m1Btlr
• Name: potassium voltage-gated channel, shaker-related subfamily, member 2; mutation 1, Bruce Beutler
• MGI ID: MGI:6304409
• Synonyms: grim
• Gene: Kcna2 Location: Chr3:107008462-107022321 bp, + strand Genetic Position: Chr3, 46.61 cM
• Alliance: Kcna2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to A transversion at base pair 107,105,027 (v38) on chromosome 3, or base pair 14,176 in the GenBank genomic region NC_000069. The mutation corresponds to residue 1,604 in the mRNA sequence NM_008417 within exon 3 of 3 total exons. The mutation results in a serine to tyrosine substitution at position 308 (S308Y) in the KCNA2 protein. (J:274750)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcna2 Mutation: 43 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3996

References

• Original: J:274750 Reyna C, et al., Mutagenetix entry for grim. MGI Direct Data Submission. 2019
• All: 1 reference(s)