Epyc^em1Yuna
Endonuclease-mediated Allele Detail

Summary

• Symbol: Epyc^em1Yuna
• Name: epiphycan; endonuclease-mediated mutation 1, Yukiko Nakamura
• MGI ID: MGI:6304421
• Gene: Epyc Location: Chr10:97479930-97517770 bp, + strand Genetic Position: Chr10, 50.35 cM, cytoband C2-C3
• Alliance: Epyc^em1Yuna page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2 bp deletion in exon 4. Western blot analysis of cochlea tissue confirmed absence of protein. (J:250746)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epyc Mutation: 21 strains or lines available

References

• Original: J:250746 Hanada Y, et al., Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing. Biochem Biophys Res Commun. 2017 Oct 21;492(3):379-385
• All: 1 reference(s)