Prkcb^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkcb^M4Btlr
• Name: protein kinase C, beta; mutation 4, Bruce Beutler
• MGI ID: MGI:6305123
• Synonyms: Mesopotamia
• Gene: Prkcb Location: Chr7:121888327-122233625 bp, + strand Genetic Position: Chr7, 65.75 cM
• Alliance: Prkcb^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 122,289,514 (v38) on chromosome 7, or base pair 390 in the GenBank genomic region NC_000073. The mutation corresponds to residue 390 in the mRNA sequence NM_008855 within exon 1 of 17 total exons. The mutation results in an isoleucine to threonine substitution at position 57 (I57T) in the PKC protein. (J:274860)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcb Mutation: 39 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4260

References

• Original: J:274860 Choi JH, et al., Mutagenetix entry for Mesopotamia. MGI Direct Data Submission. 2019
• All: 1 reference(s)