Ptprc^M11Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^M11Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 11, Bruce Beutler
• MGI ID: MGI:6305154
• Synonyms: Gentian
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^M11Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 138,067,885 (v38) on chromosome 1, or base pair 107,872 in the GenBank genomic region NC_000067 encoding Ptprc. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in the use of a cryptic site in intron 31. The resulting transcript has 29-base pair insertion of intron 31, which would cause an in-frame insertion of 10 aberrant amino acids after amino acid 1099 of the protein (which is normally 1293 amino acids long). (J:274863)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

Notes

Unknown inheritance mode. https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4266

References

• Original: J:274863 Choi JH, et al., Mutagenetix entry for Gentian. MGI Direct Data Submission. 2019
• All: 1 reference(s)