Irf8^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irf8^m2Btlr
• Name: interferon regulatory factor 8; mutation 2, Bruce Beutler
• MGI ID: MGI:6305310
• Synonyms: gemini2
• Gene: Irf8 Location: Chr8:121463097-121483433 bp, + strand Genetic Position: Chr8, 70.05 cM
• Alliance: Irf8^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 120,753,707 (v38) on chromosome 8, or base pair 17,350 in the GenBank genomic region NC_000074 encoding Irf8. The mutation corresponds to residue 1,009 in the mRNA sequence NM_008320 within exon 7 of 9 total exons. The mutation results in substitution of valine for an alanine at position 319 (V319A) in the IRF8 protein. (J:274937)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf8 Mutation: 35 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3514

References

• Original: J:274937 Zhong X, et al., Mutagenetix entry for gemini2. MGI Direct Data Submission. 2019
• All: 1 reference(s)