Nfkb2^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb2^m3Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 3, Bruce Beutler
• MGI ID: MGI:6305796
• Synonyms: lolita
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: T to C transition at base pair 46,307,720 (v38) on chromosome 19, or base pair 3,743 in the GenBank genomic regionNC_000085.The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in skipping of the 159-base pair exon 8. The mutation would cause an in-frame deletion of 53 amino acids beginning after amino acid 168 of the protein, which is normally 899 amino acids in length. (J:274960)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4296

References

• Original: J:274960 Choi JH, et al., Mutagenetix entry for lolita. MGI Direct Data Submission. 2019
• All: 1 reference(s)