Nfkb2^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb2^M4Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 4, Bruce Beutler
• MGI ID: MGI:6305800
• Synonyms: Nabukov
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: A to G transition at base pair 46,308,439 (v38) on chromosome 19, or base pair 4,120 in the GenBank genomic regionNC_000085.The mutation corresponds to residue 1,256 in the mRNA sequence NM_019408 (variant 1) within exon 10 of 22 total exons. The mutation results in an aspartic acid to glycine substitution at position 316 (D316G) in all isoforms of the NF-B2 protein. (J:274961)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4345

References

• Original: J:274961 Choi JH, et al., Mutagenetix entry for Nabukov. MGI Direct Data Submission. 2019
• All: 1 reference(s)