Nfkb2^m5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb2^m5Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 5, Bruce Beutler
• MGI ID: MGI:6305804
• Synonyms: humbert
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^m5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: G to A transition at base pair 46,307,441 (v38) on chromosome 19, or base pair 3,122 in the GenBank genomic regionNC_000085. The mutation corresponds to residue 782 in the mRNA sequence NM_019408 (variant 1) within exon 6 of 22 total exons. The mutation results in an arginine to histidine substitution at position 158 (R158H) in all isoforms of the NF-B2 protein. (J:274962)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4427

References

• Original: J:274962 Choi JH, et al., Mutagenetix entry for humbert. MGI Direct Data Submission. 2019
• All: 1 reference(s)