Tg(HBB*)L2Pai
Transgene Detail

Summary

• Symbol: Tg(HBB*)L2Pai
• Name: transgene insertion L2, Panayiotis A Ioannou
• MGI ID: MGI:6306307
• Synonyms: ^huBeta^delta4bp
• Transgene: Tg(HBB*)L2Pai Location: unknown
• Alliance: Tg(HBB*)L2Pai page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HBB*)L2Pai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBB (3043)

  Hbb-b1	(MGI:96021)
  Hbb-b2	(MGI:96022)
  Hbb-bh2	(MGI:96025)
  Hbb-bs	(MGI:5474852)
  Hbb-bt	(MGI:5474850)

  human locus with 41-42 codon 4-bp deletion

• Mutation details: This transgene contains a 183-kb fragment of the human beta-globin locus with the codons 41-42 (-TTCT) deletion mutation. The L2 line contains six copies of the transgene. RT-PCR and sequencing indicated the production of a 156-bp product confirming the presence of the 4-bp deletion. In addition, a 118-bp PCR product was also detected and sequencing of this aberrant splicing product indicates a deletion of 38-bp of exon 1 (codons 18-30). (J:97548)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97548 Jamsai D, et al., A humanized mouse model for a common beta0-thalassemia mutation. Genomics. 2005 Apr;85(4):453-61
• All: 1 reference(s)