Hspa12a^tm1.1Zdi
Targeted Allele Detail

Summary

• Symbol: Hspa12a^tm1.1Zdi
• Name: heat shock protein 12A; targeted mutation 1.1, Zhengnian Ding
• MGI ID: MGI:6306701
• Synonyms: Hspa12a^-
• Gene: Hspa12a Location: Chr19:58784182-58932086 bp, - strand Genetic Position: Chr19, 54.51 cM
• Alliance: Hspa12a^tm1.1Zdi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. Immunoblots and immunohistochemistry confirmed the absence of peptide expression from this allele. (J:271786)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa12a Mutation: 39 strains or lines available

References

• Original: J:271786 Mao Y, et al., Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1862-1872
• All: 9 reference(s)