Gtf2ird2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gtf2ird2^em1(IMPC)J
• Name: GTF2I repeat domain containing 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6307004
• Gene: Gtf2ird2 Location: Chr5:134211629-134246988 bp, + strand Genetic Position: Chr5, 74.45 cM
• Alliance: Gtf2ird2^em1(IMPC)J page
• IMPC: Gtf2ird2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ATTGCCCTAGATGAAGCTGG and CTAAACAGGCTGTCAGGCTC, which resulted in a 257 bp deletion beginning at Chromosome 5 position 134,196,365 bp and ending after 134,196,621 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001266451 (exon 5) and 73 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 117 and early truncation 2 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gtf2ird2 Mutation: 47 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)