Prss3b^tm1.1Satom
Targeted Allele Detail

Summary

• Symbol: Prss3b^tm1.1Satom
• Name: serine protease 3B; targeted mutation 1.1, Miklos Sahin-Toth
• MGI ID: MGI:6307777
• Synonyms: T7^D23A
• Gene: Prss3b Location: Chr6:41007202-41012443 bp, - strand Genetic Position: Chr6, 19.1 cM
• Alliance: Prss3b^tm1.1Satom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267764
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: Exon 2 was modified to produce the amino acid substitution of alanine for aspartic acid at position 23 (D23A). This mutation autoactivates to trypsin 50-fold faster than wild type. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted into intron 1. (J:267764)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss3b Mutation: 23 strains or lines available

Notes

C57BL/6 embryonic stem (ES) cells (Cyagen, Santa Clara, CA)

References

• Original: J:267764 Geisz A, et al., A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation. Nat Commun. 2018 Nov 28;9(1):5033
• All: 1 reference(s)