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Tg(Itgam-FCAR)83Rcmo
Transgene Detail
Summary
Symbol: Tg(Itgam-FCAR)83Rcmo
Name: transgene insertion 83, Renato C Monteiro
MGI ID: MGI:6313615
Synonyms: CD89 Tg
Transgene: Tg(Itgam-FCAR)83Rcmo  Location: unknown  
Alliance: Tg(Itgam-FCAR)83Rcmo page
Transgene
origin
Strain of Origin:  NOD
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Itgam-FCAR)83Rcmo expresses 1 gene
 
Tg(Itgam-FCAR)83Rcmo expression driven by 1 gene
 
Mutation detailsThe human Fc Fragment of IgA Receptor (CD89) a.1 isoform in under the control of the 1.7-kb mouse Itgam (CD11b) promoter that confers high levels of expression on monocyte/macrophages. Three lines, 73, 83, and 96 were generated. The level of transgene expression is about 10-fold higher on macrophages from line 83 than the other two lines. (J:120534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:120534 Launay P, et al., Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice. J Exp Med. 2000 Jun 5;191(11):1999-2009
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory