Tg(MMTV-Scgb1a1)#Abm
Transgene Detail

Summary

• Symbol: Tg(MMTV-Scgb1a1)#Abm
• Name: transgene insertion, Anil B Mukherjee
• MGI ID: MGI:6313626
• Synonyms: AS-UG
• Transgene: Tg(MMTV-Scgb1a1)#Abm Location: unknown
• Alliance: Tg(MMTV-Scgb1a1)#Abm page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Knockdown)
• Mutation: Insertion
• Tg(MMTV-Scgb1a1)#Abm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Scgb1a1 (MGI:98919)

• Mutation details: A full-length mouse Scgb1a1 cDNA in its antisense orientation is under the control of the MMTV-LTR promoter. Two lines were established, however the pound (#) sign is used as line numbers are not provided. Western blot analysis confirmed that levels of the Scgb1a1 protein were reduced in the lungs and prostate confirming that antisense RNA expression suppresses protein expression. (J:57504)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:57504 Zheng F, et al., Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. Nat Med. 1999 Sep;5(9):1018-25
• All: 1 reference(s)