Deptor^tm1.1Mala
Targeted Allele Detail

Summary

• Symbol: Deptor^tm1.1Mala
• Name: DEP domain containing MTOR-interacting protein; targeted mutation 1.1, Mathieu Laplante
• MGI ID: MGI:6314233
• Synonyms: Deptor^LoxP
• Gene: Deptor Location: Chr15:54975824-55122667 bp, + strand Genetic Position: Chr15, 21.96 cM
• Alliance: Deptor^tm1.1Mala page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275931
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector used the gene from BAC RP24-167K18 and inserted the following elements around exon 2: a loxP site, an FRT site, a neomycin resistance gene cassette, an FRT site and a loxP site into intron 1, and a third loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:275931)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Deptor Mutation: 29 strains or lines available

References

• Original: J:275931 Caron A, et al., Loss of hepatic DEPTOR alters the metabolic transition to fasting. Mol Metab. 2017 May;6(5):447-458
• All: 2 reference(s)