Nkx2-5^tm1.1Krc
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1.1Krc
• Name: NK2 homeobox 5; targeted mutation 1.1, Kenneth R Chien
• MGI ID: MGI:6314342
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1.1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273096
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The floxed exon 2 was deleted via cre-mediated recombination. (J:273096)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:273096 Ashraf H, et al., A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation. Circ Cardiovasc Genet. 2014 Aug;7(4):423-433
• All: 1 reference(s)