Ranbp1^{Gt(S17-6E1)1.1Sor}
Gene trapped Allele Detail

Summary

• Symbol: Ranbp1^{Gt(S17-6E1)1.1Sor}
• Name: RAN binding protein 1; gene trap S17-6E1, 1.1, Philippe Soriano
• MGI ID: MGI:6314348
• Synonyms: Ranbp1^-
• Gene: Ranbp1 Location: Chr16:18057843-18066558 bp, - strand Genetic Position: Chr16, 11.3 cM
• Alliance: Ranbp1^{Gt(S17-6E1)1.1Sor} page

Mutation origin

• Mutant Cell Line: S17-6E1
• Germline Transmission: Earliest citation of germline transmission: J:235630
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: The insertion site was mapped to the 98th base of exon 2 of Ranbp1. The beta-geo reporter is almost undetectable due to the atypical insertion of the reporter into the exon rather than intron. The hygromycin cassette was excised via Flp-mediated recombination. Western blotting and immunofluorescence staining confirmed absence of protein and no 44 amino acid residual protein is detected. (J:235630)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ranbp1 Mutation: 69 strains or lines available

References

• Original: J:235630 Paronett EM, et al., Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation. Cereb Cortex. 2015 Oct;25(10):3977-93
• All: 2 reference(s)