Calm1^em1Gkim
Endonuclease-mediated Allele Detail

Summary

• Symbol: Calm1^em1Gkim
• Name: calmodulin 1; endonuclease-mediated mutation 1, Geumsoo Kim
• MGI ID: MGI:6315239
• Synonyms: M77Q Calm1
• Gene: Calm1 Location: Chr12:100165694-100176073 bp, + strand Genetic Position: Chr12, 50.43 cM
• Alliance: Calm1^em1Gkim page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing was used to insert an amino acid substitution at position 77 altering methionine to glutamine (M77Q - ATG to CAG). (J:272366)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calm1 Mutation: 23 strains or lines available

References

• Original: J:272366 Marimoutou M, et al., Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior. Antioxidants (Basel). 2018 Oct 13;7(10)
• All: 1 reference(s)