Tavq1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tavq1^DBA/2J
• Name: total attack value QTL 1; DBA/2J
• MGI ID: MGI:6315269
• QTL: Tavq1 Location: Chr1:81977715-88427722 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:276034

Aggression between male conspecifics is a complex social behavior that is likely modulated by multiple gene variants. In this study, the BXD recombinant inbred mouse strains (RIS) were used to map QTL underlying behaviors associated with intermale aggression.

Four hundred and fifty-seven males from 55 BXD strains (including the parental strains C57BL/6J and DBA/2J) were observed at an age of 13 +/- 1 week in a resident-intruder test following 10 days of isolation. Attack latency was measured directly within a 10-minute time period and the test was repeated 24 hours later. The variables analyzed were the proportion of attacking males in a given strain as well as the attack latency (on days 1 and 2, and both days combined).

On day 1, 29% of males attacked, and this increased to 37% on day 2. Large strain differences were obtained for all measures of aggression, indicating substantial heritability (intraclass correlations 0.10-0.18).

The QTL mapping module of GeneNetwork was used to identify QTL for the aggression trait data.

The authors identified three significant QTL on Chr 1 (all coordinates relative to GRCm38):

QTL Malq1 (mean attack latency QTL 1) maps to Chr 1:78.0 - 88.0 Mb with a peak LRS value of 17.1 at 83.9 Mb near rs13475957.

QTL Tavq1 (total attack value QTL 1) maps to Chr 1:82.0 - 88.5 Mb with a peak LRS value of 21.1 at 83.9 Mb near rs13475957.

QTL Avd2q1 (attack value day 2 QTL 1) maps to Chr1:79.0 - 91.0 Mb with a peak LRS value of 19.1 at 83.9 Mb near rs13475957.

The C57BL/6J allele increases aggression scores and explains about 18% of the variance.

The most likely candidate gene modulating these QTL is Htr2b, which encodes the serotonin 2B receptor and has been implicated in aggressive and impulsive behavior in mice, humans and other species.

Several suggestive QTL were also identified in this study.

References

• Original: J:276034 Delprato A, et al., A quantitative trait locus on chromosome 1 modulates intermale aggression in mice. Genes Brain Behav. 2018 Sep;17(7):e12469
• All: 1 reference(s)