Chrdl1^em1Nja
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chrdl1^em1Nja
• Name: chordin-like 1; endonuclease-mediated mutation 1, Nicola J Allen
• MGI ID: MGI:6315865
• Gene: Chrdl1 Location: ChrX:142068670-142177258 bp, - strand Genetic Position: ChrX, 64.24 cM, cytoband F3
• Alliance: Chrdl1^em1Nja page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 produced a 2 nucleotide deletion that results in a frameshift and premature stop codon. (J:269376)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrdl1 Mutation: 13 strains or lines available

References

• Original: J:269376 Blanco-Suarez E, et al., Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors. Neuron. 2018 Dec 5;100(5):1116-1132.e13
• All: 2 reference(s)