Rhpn1^tm1Ktry
Targeted Allele Detail

Summary

• Symbol: Rhpn1^tm1Ktry
• Name: rhophilin, Rho GTPase binding protein 1; targeted mutation 1, Karl Tryggvason
• MGI ID: MGI:6316664
• Synonyms: Rhpn1ko
• Gene: Rhpn1 Location: Chr15:75576097-75586268 bp, + strand Genetic Position: Chr15, 34.76 cM, cytoband E1
• Alliance: Rhpn1^tm1Ktry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276466
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Exons 1-4 were replaced with an in-frame GFP coding sequence downstream of the ATG start codon. (J:276466)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhpn1 Mutation: 34 strains or lines available

References

• Original: J:276466 Lal MA, et al., Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration. J Am Soc Nephrol. 2015 Mar;26(3):647-62
• All: 1 reference(s)